摘要：

猪流行性腹泻病毒（Porcine epidemic diarrhea virus，PEDV）作为生猪养殖业的高危病原体之一，给全球生猪养殖业造成了重大威胁。由于病毒的高变异性和免疫逃逸特性，对传统疫苗及化学防控药物构成了严峻的挑战。基于中药复方多靶点的协同干预作用，中药已成为当前抗病毒研究领域的热点方向之一。笔者针对中药防控猪流行性腹泻（PED）的国内外研究进展进行了全面综述，对最新中药组方的防控效果和作用机制进行了系统性归纳。同时，结合中药现代化技术，涉及人工智能、网络药理学、中药纳米化、中药益生菌发酵等技术进行中药增效的多途径、多策略的梳理汇总，并展望了中药防治PED的发展方向和应用前景，为PED的防控提供更安全、更有效的中药复合制剂，也为其他动物病毒性疾病的防控提供了参考。

关键词: 猪流行性腹泻病毒（PEDV）; 中药防治; 增效策略; 中药发酵; 中药纳米化

Abstract:

Porcine epidemic diarrhea virus （PEDV） is one of the high-risk pathogens in the pig farming industry and poses a significant threat to global pig farming. More seriously， due to the high variability of the virus and its immune escape characteristics， it poses a more severe challenge to traditional vaccines and chemical control drugs. Based on the multi-target synergistic intervention effect of traditional Chinese medicine （TCM） formulas， TCM has become one of the hot directions in the current antiviral research field. This paper comprehensively reviews the domestic and international research progress of TCM in the prevention and control of porcine epidemic diarrhea （PED）， and systematically summarizes the prevention and control effects and mechanisms of action of the latest TCM formulas. At the same time， combined with modern TCM technology， involving technologies such as artificial intelligence， network pharmacology， TCM nanotechnology， and TCM probiotic fermentation， it sorts out and summarizes the multi-path and multi-strategy enhancement of TCM， and looks forward to the development direction and application prospects of TCM in the prevention and treatment of PED， providing safer and more effective TCM compound preparations for the prevention and control of PED， and also providing reference for the prevention and control of other animal viral diseases.

Key words: Porcine epidemic diarrhea virus （PEDV）; prevention and treatment with traditional Chinese medicine; strategies to increase efficiency; fermentation of traditional Chinese medicine; nanoparticle modification of traditional Chinese medicine

中图分类号: 

• S859.31